| Schauspieler | Rolle | Synchronsprecher | ||
| Robert Downey Jr. Robert Downey Jr. | Sherlock Holmes | Charles Rettinghaus Charles Rettinghaus | ||
| Jude Law Jude Law | Dr. John Watson | Florian Halm Florian Halm | ||
| Mark Strong Mark Strong | Lord Blackwood | Tom Vogt Tom Vogt | ||
| Rachel McAdams Rachel McAdams | Irene Adler | Ranja Bonalana | ||
| Joe Egan | Big Joe | Stefan Fredrich Stefan Fredrich | ||
| James A. Stephens | Captain Philips | Bert Franzke Bert Franzke | ||
| Andrew Brooke | Captain | Thomas Nero Wolff Thomas Nero Wolff | ||
| Clive Russell | Captain Tanner | Peter Groeger Peter Groeger | ||
| William Houston | Constable Clark | Bernd Vollbrecht Bernd Vollbrecht | ||
| Jonathan Gabriel Robbins | Constable im Gefängnis | Sascha Rotermund Sascha Rotermund | ||
| Robert Maillet | Dredger | Nicht synchronisiert | ||
| Terence Taplin | Friedhofs-Wächter | Thomas Hailer | ||
| Ned Dennehy | Ganove mit Rosen | Thomas Petruo Thomas Petruo | ||
| Andrew Greenough | Gefängniswärter | Tobias Meister Tobias Meister | ||
| James Greene | Gouverneur | Gerd Holtenau Gerd Holtenau | ||
| Bronagh Gallagher | Hellseherin | Philine Peters-Arnolds Philine Peters-Arnolds | ||
| Eddie Marsan Eddie Marsan | Inspector Lestrade | Stefan Krause Stefan Krause | ||
| William Hope | John Standish | Udo Schenk | ||
| Kelly Reilly | Mary Morstan | Alexandra Wilcke Alexandra Wilcke | ||
| Hans Matheson | Lord Coward | Sven Hasper | ||
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