| Schauspieler | Rolle | Synchronsprecher | ||
| Danny Trejo Danny Trejo | Machete Cortez | Thomas Wolff | ||
| Robert De Niro Robert De Niro | Senator John McLaughlin | Christian Brückner Christian Brückner | ||
| Michelle Rodriguez Michelle Rodriguez | Luz | Anke Reitzenstein Anke Reitzenstein | ||
| Jessica Alba Jessica Alba | Sartana Rivera | Stephanie Kellner Stephanie Kellner | ||
| Lindsay Lohan | April Booth | Maria Koschny Maria Koschny | ||
| Billy Blair | Billy | Thomas Petruo Thomas Petruo | ||
| Felix Sabates | Doc Felix | Michael Iwannek Michael Iwannek | ||
| Daryl Sabara | Julio | Ricardo Richter Ricardo Richter | ||
| Elise Avellan | Lisa | Verena Mehnert Verena Mehnert | ||
| Dimitrius Pulido | Bodyguard | Rainer Fritzsche Rainer Fritzsche | ||
| Alcides Dias | Bodyguard #2 | Thomas Schmuckert | ||
| Nina Leon | Machetes Frau | Svantje Wascher Svantje Wascher | ||
| Jeff Fahey | Michael Booth | Tom Vogt Tom Vogt | ||
| Tom Savini | Osiris Amanpour | Jan Spitzer Jan Spitzer | ||
| Shea Whigham | Sniper | Lutz Schnell Lutz Schnell | ||
| Jason Douglas | Tankwart #1 | Matthias Rimpler | ||
| Steven Seagal Steven Seagal | Torrez | Ekkehardt Belle Ekkehardt Belle | ||
| Cheech Marin Cheech Marin | Vater Cortez | Ronald Nitschke Ronald Nitschke | ||
| Don Johnson Don Johnson | Von Jackson | Reent Reins Reent Reins | ||
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