| Schauspieler | Rolle | Synchronsprecher | ||
| Rosa Blasi | Dr. Luisa 'Lu' Delgado | Irina von Bentheim Irina von Bentheim | ||
| Jenifer Lewis | Rezeptionistin Lana Hawkins | Joseline Gassen Joseline Gassen | ||
| Joshua Cox | Peter Riggs | Peter Flechtner Peter Flechtner | ||
| Philip Casnoff | Dr. Robert 'Bob' Jackson | Thomas Nero Wolff Thomas Nero Wolff | ||
| Brennan Elliott | Dr. Nick Biancavilla | Sven Hasper | ||
| Janine Turner | Dr. Dana Stowe | Daniela Strietzel | ||
| Chris Marquette | Marc Delgado | Nico Sablik Nico Sablik | ||
| Susan Blakely | Camille Cantrell | Andrea Aust Andrea Aust | ||
| Debbi Morgan | Chloe Simons | Martina Treger Martina Treger | ||
| Whoopi Goldberg Whoopi Goldberg | Dr. Lydia Emerson | Regina Lemnitz Regina Lemnitz | ||
| Michael Town | E.R. Doc Morrow | Sebastian Christoph Jacob Sebastian Christoph Jacob | ||
| Rebekah Ryan | Kadi | Kellina Klein | ||
| Jerry Gelb | Ken | Matthias Klages Matthias Klages | ||
| Bryan Greenberg | Kent | Sebastian Walch | ||
| Holland Taylor | Lillian Pynchon | Gisela Fritsch | ||
| Emy Coligado | Schwester Betsy Welling | Kellina Klein | ||
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