| Schauspieler | Rolle | Synchronsprecher | ||
| Reeve Carney | Dorian Gray | Arne Stephan Arne Stephan | ||
| Timothy Dalton Timothy Dalton | Sir Malcolm Murray | Lutz Riedel Lutz Riedel | ||
| Eva Green Eva Green | Vanessa Ives | Katrin Zimmermann | ||
| Simon Russell Beale | Ferdinand Lyle | Lutz Mackensy Lutz Mackensy | ||
| Harry Treadaway Harry Treadaway | Dr. Victor Frankenstein | David Turba David Turba | ||
| Rory Kinnear | Die Kreatur | Frank Schaff Frank Schaff | ||
| Josh Hartnett Josh Hartnett | Ethan Chandler | Simon Jäger Simon Jäger | ||
| Danny Sapani | Sembene | Hans Hohlbein Hans Hohlbein | ||
| Douglas Hodge Douglas Hodge | Bartholomew Rusk | Frank Röth Frank Röth | ||
| Sarah Greene | Hecate Poole | Marieke Oeffinger Marieke Oeffinger | ||
| Helen McCrory | Madame Kali | Arianne Borbach Arianne Borbach | ||
| Billie Piper | Brona Croft | Nadine Zaddam | ||
| Patti LuPone | Joan Clayton / Dr. Seward | Silke Matthias | ||
| Christian Camargo | Dr. Alexander Sweet | Nico Mamone | ||
| Shazad Latif | Dr. Henry Jekyll | Tim Knauer Tim Knauer | ||
| Wes Studi | Kaetenay | Axel Lutter Axel Lutter | ||
| Samuel Barnett | Renfield | Patrick Baehr Patrick Baehr | ||
| Jonny Beauchamp | Angelique | Dirk Petrick Dirk Petrick | ||
| Joseph Millson | Captain Branson | Martin Lohmann | ||
| Mary Stockley | Caroline | Susanne Geier | ||
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