| Schauspieler | Rolle | Synchronsprecher | ||
| Kenneth Branagh Kenneth Branagh | Victor Frankenstein | Ulrich Matthes | ||
| Helena Bonham Carter Helena Bonham Carter | Elisabeth | Melanie Pukaß Melanie Pukaß | ||
| Sir Ian Holm Sir Ian Holm | Baron Frankenstein | Hermann Ebeling | ||
| John Cleese John Cleese | Professor Waldman | Friedhelm Ptok Friedhelm Ptok | ||
| Robert De Niro Robert De Niro | Kreatur (Frankensteins Monster) | Christian Brückner Christian Brückner | ||
| Cherie Lunghi | Caroline Beaufort Frankenstein | Karin Grüger | ||
| Gerard Horan | Claude | Reinhard Scheunemann Reinhard Scheunemann | ||
| Mark Hadfield | Felix | Stefan Krause Stefan Krause | ||
| Susan Field | Frau Brach | Christel Merian | ||
| Jimmy Yuill | Grigori | Roland Hemmo Roland Hemmo | ||
| Richard Briers | Großvater | Erhard Köster | ||
| Tom Hulce | Henry Clerval | Detlev Eckstein | ||
| Trevyn McDowell | Justine | Ulrike Stürzbecher Ulrike Stürzbecher | ||
| Sasha Hanau | Maggie | Viola Scherff | ||
| Joanna Roth | Marie | Bettina Weiß Bettina Weiß | ||
| Celia Imrie | Mrs. Moritz | Ursula Werner | ||
| Richard Clifford | Priester | Bernd Vollbrecht Bernd Vollbrecht | ||
| Robert Hardy | Professor Krempe | Hasso Zorn | ||
| Joseph England | Thomas | Wanja Gerick | ||
| Jenny Galloway | Verkäuferin | Eva-Maria Werth | ||
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