| Schauspieler | Rolle | Synchronsprecher | ||
| Winona Ryder Winona Ryder | Susanna Kaysen | Kellina Klein | ||
| Angelina Jolie Angelina Jolie | Lisa Rowe | Claudia Urbschat Mingues Claudia Urbschat Mingues | ||
| Clea DuVall Clea DuVall | Georgina Tuskin | Julia Ziffer Julia Ziffer | ||
| Brittany Murphy Brittany Murphy | Daisy Randone | Ghadah Al-Akel | ||
| Elisabeth Moss | Polly 'Glühwürmchen' Clark | Natascha Petz | ||
| Jared Leto Jared Leto | Tobias 'Toby' Jacobs | Dietmar Wunder Dietmar Wunder | ||
| Kurtwood Smith Kurtwood Smith | Dr. Crumble | Roland Hemmo Roland Hemmo | ||
| Jeffrey Tambor Jeffrey Tambor | Dr. Melvin Potts | Bert Franzke Bert Franzke | ||
| Vanessa Redgrave Vanessa Redgrave | Dr. Sonia Wick | Judy Winter Judy Winter | ||
| Whoopi Goldberg Whoopi Goldberg | Valerie Owens | Regina Lemnitz Regina Lemnitz | ||
| Angela Bettis | Janet Webber | Claudia Lehmann Claudia Lehmann | ||
| Jillian Armenante | Cynthia Crowley | Almut Zydra Almut Zydra | ||
| Drucie McDaniel | M.G. | Irina von Bentheim Irina von Bentheim | ||
| Alison Claire | Schwester Gretta | Gabrielle Scharnitzky | ||
| Christina Myers | Schwester Margie | Ulrike Stürzbecher Ulrike Stürzbecher | ||
| Joanna Kerns | Annette Kaysen | Gertie Honeck | ||
| Gloria Barnhart | ältere katatonische Frau | Eva-Maria Werth | ||
| Ginny Graham | Arleen | Renate Danz | ||
| C. Scott Grimaldi | Arzt in Notaufnahme | Andreas Müller Andreas Müller | ||
| Mary Kay Place | Barbara Gilcrest | Margot Rothweiler Margot Rothweiler | ||
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