| Schauspieler | Rolle | Synchronsprecher | ||
| Robert Downey Jr. Robert Downey Jr. | Sherlock Holmes | Charles Rettinghaus Charles Rettinghaus | ||
| Jude Law Jude Law | Dr. John Watson | Florian Halm Florian Halm | ||
| Rachel McAdams Rachel McAdams | Irene Adler | Ranja Bonalana | ||
| Noomi Rapace Noomi Rapace | Madam Simza Heron | Sandra Schwittau Sandra Schwittau | ||
| Jared Harris Jared Harris | Professor James Moriarty | Frank Glaubrecht Frank Glaubrecht | ||
| Stephen Fry Stephen Fry | Mycroft Holmes | Frank-Otto Schenk Frank-Otto Schenk | ||
| Thierry Neuvic | Claude Ravache | Tobias Kluckert Tobias Kluckert | ||
| Paul Anderson | Colonel Sebastian Moran | Peter Flechtner Peter Flechtner | ||
| William Houston | Constable Clark | Bernd Vollbrecht Bernd Vollbrecht | ||
| Iain Mitchell | Auktionator | Reinhard Kuhnert Reinhard Kuhnert | ||
| Wolf Kahler | Doktor Hoffmanstahl | Bodo Wolf Bodo Wolf | ||
| Eddie Marsan Eddie Marsan | Inspector Lestrade | Stefan Krause Stefan Krause | ||
| Kelly Reilly | Mary Watson | Alexandra Wilcke Alexandra Wilcke | ||
| Affif Ben Badra | Tamas | Patrice Luc D. Patrice Luc D. | ||
| Geraldine James | Mrs. Hudson | Marianne Groß Marianne Groß | ||
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