| Schauspieler | Rolle | Synchronsprecher | ||
| Benedict Cumberbatch Benedict Cumberbatch | Patrick Melrose | Tommy Morgenstern Tommy Morgenstern | ||
| Jennifer Jason Leigh Jennifer Jason Leigh | Eleanor Melrose | Alexandra Ludwig Alexandra Ludwig | ||
| Jessica Raine | Julia | Susanne Geier | ||
| Hugo Weaving Hugo Weaving | David Melrose | Wolfgang Condrus Wolfgang Condrus | ||
| Georgia Maguire | Amanda Pratt | Angelina Geisler | ||
| Beatrice Curnew | Angie | Sandra Maria Fronterré | ||
| Indira Varma | Anne Moore | Gundi Eberhard Gundi Eberhard | ||
| Eileen Walsh | Annette | Sandrine Mittelstädt Sandrine Mittelstädt | ||
| Matthew Marsh | Ballentine Morgan | Sven Brieger Sven Brieger | ||
| Natalie Klamar | Becky | Cathlen Gawlich Cathlen Gawlich | ||
| Lila Prideaux | Belinda Gravesend | Carlotta Saura | ||
| Kerry Shale | Bestatter | Freimut Götsch Freimut Götsch | ||
| Holliday Grainger | Bridget Watson Scott | Maria Hönig | ||
| Gary Beadle | Chilly Willy | Tim Moeseritz Tim Moeseritz | ||
| Margo Stilley | Cindy Smith | Sandrine Mittelstädt Sandrine Mittelstädt | ||
| Guy Paul | Cousin Henry | Boris Freytag | ||
| Morfydd Clark | Debbie Hickman | Victoria Frenz Victoria Frenz | ||
| Naoko Mori | Dr. Pagazzi | Bianca Karsten | ||
| Janine Harouni | Empfangsdame | Sandra Maria Fronterré | ||
| David Mills | Empfangsmitarbeiter | Sebastian Kaufmane Sebastian Kaufmane | ||
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