| Schauspieler | Rolle | Synchronsprecher | ||
| Robin Williams Robin Williams | Patch Adams | Peer Augustinski Peer Augustinski | ||
| Daniel London | Truman | Timmo Niesner Timmo Niesner | ||
| Monica Potter Monica Potter | Carin | Maud Ackermann Maud Ackermann | ||
| Philip Seymour Hoffman Philip Seymour Hoffman | Mitch | Torsten Münchow Torsten Münchow | ||
| Daniella Kuhn | Adelane | Angela Ringer | ||
| Ellen Albertini Dow | Aggie Kennedy | Tilly Lauenstein | ||
| Harold Gould | Arthur Mendelson | Friedrich Schoenfelder Friedrich Schoenfelder | ||
| James Greene I | Bile | Peter Groeger Peter Groeger | ||
| Peter Coyote | Bill Davis | Bernd Schramm | ||
| Bob Gunton Bob Gunton | Dean Walcott | Gunter Schoß | ||
| Harve Presnell | Dekan J.P. Anderson | Jochen Schröder Jochen Schröder | ||
| Josef Sommer | Dr. Eaton | Gerd Holtenau Gerd Holtenau | ||
| Harry Groener | Dr. Prack | Jan Spitzer Jan Spitzer | ||
| Richard Kiley | Dr. Titan | Lothar Blumhagen Lothar Blumhagen | ||
| Alan Tudyk | Everton | Michael Walke | ||
| Ismael 'East' Carlo | Hispanischer Vater | Elmar Gutmann | ||
| Jay Jacobus | Jack Walton, älterer Patient | Alexander Herzog | ||
| Irma P. Hall | Joletta | Regina Lemnitz Regina Lemnitz | ||
| Frances Lee McGain | Judy | Barbara Adolph Barbara Adolph | ||
| Douglas Roberts | Larry | Stefan Fredrich Stefan Fredrich | ||
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