| Schauspieler | Rolle | Synchronsprecher | ||
| Paul Giamatti Paul Giamatti | Abraham Zapruder | Stefan Krause Stefan Krause | ||
| James Badge Dale | Robert Oswald | Alexander Doering | ||
| David Harbour | Gordon Shanklin | Peter Flechtner Peter Flechtner | ||
| Zac Efron Zac Efron | Dr. Charles 'Jim' Carrico | Daniel Schlauch Daniel Schlauch | ||
| Ron Livingston | James Hosty | Olaf Reichmann Olaf Reichmann | ||
| Jacki Weaver | Marguerite Oswald | Katharina Lopinski | ||
| Marcia Gay Harden | Schwester Doris Nelson | Martina Treger Martina Treger | ||
| Billy Bob Thornton Billy Bob Thornton | Forrest Sorrels | Joachim Tennstedt Joachim Tennstedt | ||
| Colin Hanks | Dr. Malcolm Perry | Julien Haggége Julien Haggége | ||
| Austin Nichols | Emory Roberts | Ricardo Richter Ricardo Richter | ||
| Mark Duplass | Kenneth O'Donnell | Marius Clarén Marius Clarén | ||
| Tom Welling | Roy Kellerman | Timmo Niesner Timmo Niesner | ||
| Jason Douglas | Ken Howe | Tobias Meister Tobias Meister | ||
| Gil Bellows Gil Bellows | David Powers | Wolfgang Wagner | ||
| Rory Cochrane | Earl Rose | Matthias Deutelmoser Matthias Deutelmoser | ||
| Mallory Moye | Schwester #1 | Nicole Hannak Nicole Hannak | ||
| Drew Waters | Col. James Swindal | Sven Hasper | ||
| Walt Roberts | Dallas Police Detective | Detlef Bierstedt Detlef Bierstedt | ||
| Paul Sparks Paul Sparks | Harry McCormick | Stefan Gossler Stefan Gossler | ||
| Kat Steffens | Jacqueline 'Jackie' Kennedy | Gundi Eberhard Gundi Eberhard | ||
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