| Schauspieler | Rolle | Synchronsprecher | ||
| Gabourey Sidibe Gabourey Sidibe | Precious | Dela Dabulamanzi | ||
| Rodney 'Bear' Jackson | Carl | Milton Welsh Milton Welsh | ||
| Angelic Zambrana | Consuelo | Nora Abdel-Maksoud | ||
| Sherri Shepherd | Cornrows | Isabella Grothe | ||
| Amina Robinson | Jermaine | Eva Bay | ||
| Xosha Roquemore | Joann | Stella Hilb | ||
| Lenny Kravitz Lenny Kravitz | Krankenpfleger John | Robert Glatzeder Robert Glatzeder | ||
| Kimberly Russell | Katherine | Anna Barbara Kurek | ||
| Mo'Nique | Mary | Rosalind Baffoe | ||
| Quisha Powell | Mongo | Sarah Kunze | ||
| Linda Watson | Miss Turner | Sabine Falkenberg Sabine Falkenberg | ||
| Bill Sage | Mr. Wicher | Bernd Vollbrecht Bernd Vollbrecht | ||
| Nealla Gordon | Mrs. Lichtenstein | Gabriele Streichhahn-Schott | ||
| Paula Patton Paula Patton | Ms. Rain | Sanam Afrashteh Sanam Afrashteh | ||
| Chyna Layne | Rhonda | Marie Grobe | ||
| Mariah Carey | Mrs. Weiss | Vera Teltz Vera Teltz | ||
| Stephanie Andujar | Rita | Anja Stadlober | ||
| Aunt Dot | Tootsie | Luise Lunow Luise Lunow | ||
| Victor Woodley | ungezogener Junge | Benjamin Stöwe Benjamin Stöwe | ||
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