| Schauspieler | Rolle | Synchronsprecher | ||
| Bill Murray Bill Murray | Frank Detomello | Arne Elsholtz Arne Elsholtz | ||
| Chris Elliott | Bob | Gudo Hoegel Gudo Hoegel | ||
| Elena Franklin | Shane | Gabrielle Pietermann | ||
| Antonio Fargas | Chill | Horst Sachtleben Horst Sachtleben | ||
| Brandy Norwood | Leah | Katrin Fröhlich Katrin Fröhlich | ||
| William Shatner William Shatner | Mayor Phlegmming | Lambert Hamel | ||
| Chris Rock Chris Rock | Osmosis Jones | Jan Odle Jan Odle | ||
| Laurence Fishburne Laurence Fishburne | Thrax | Ole Pfennig | ||
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