| Schauspieler | Rolle | Synchronsprecher | ||
| Jack Black Jack Black | Po | Hape Kerkeling | ||
| Lucy Liu Lucy Liu | Viper | Cosma Shiva Hagen | ||
| Angelina Jolie Angelina Jolie | Tigress | Bettina Zimmermann | ||
| Dustin Hoffman Dustin Hoffman | Shifu | Gottfried John | ||
| David Cross | Crane | Ralf Schmitz | ||
| Gary Oldman Gary Oldman | Lord Shen | Hans-Jürgen Dittberner Hans-Jürgen Dittberner | ||
| Seth Rogen Seth Rogen | Mantis | Tobias Kluckert Tobias Kluckert | ||
| Jean-Claude van Damme Jean-Claude van Damme | Meister Croco | Lutz Schnell Lutz Schnell | ||
| Victor Garber | Meister Donnerndes Nashorn | Bodo Wolf Bodo Wolf | ||
| Dennis Haysbert | Meister Ochse | Dieter B. Gerlach Dieter B. Gerlach | ||
| James Hong | Mr. Ping (Pos Vater) | Lutz Mackensy Lutz Mackensy | ||
| Jackie Chan Jackie Chan | Monkey | Stefan Gossler Stefan Gossler | ||
| Fred Tatasciore | Pos Panda Vater | Klaus Lochthove Klaus Lochthove | ||
| Michelle Yeoh | Wahrsagerin / Erzählerin | Arianne Borbach Arianne Borbach | ||
| Danny McBride Danny McBride | Wolf Boss | Jörg Hengstler Jörg Hengstler | ||
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