| Schauspieler | Rolle | Synchronsprecher | ||
| Dame Judi Dench Dame Judi Dench | Philomena | Kerstin de Ahna Kerstin de Ahna | ||
| Steve Coogan Steve Coogan | Martin Sixsmith | Manfred Trilling | ||
| Sophie Kennedy Clark | Philomena (jung) | Marcia von Rebay | ||
| Mare Winningham | Mary | Sandra Schwittau Sandra Schwittau | ||
| Barbara Jefford | Schwester Hildegard | Ilona Grandke | ||
| Ruth McCabe | Mutter Barbara | Angelika Bender | ||
| Peter Hermann | Pete Olsson | Stefan Lehnen | ||
| Sean Mahon | Michael | Manou Lubowski Manou Lubowski | ||
| Anna Maxwell Martin | Jane | Andrea Wick | ||
| Michelle Fairley | Sally Mitchell | Kathrin Simon | ||
| Elliot Levey | Alex | Claus Peter Damitz Claus Peter Damitz | ||
| Frankie McCafferty | Barkeeper | Uwe Kosubek | ||
| Charles Edwards | David | Jakob Riedl | ||
| Nicholas Jones | Dr. Robert | Leon Rainer | ||
| D.J. McGrath | John | Tim Schwarzmaier | ||
| Simone Lahbib | Kate Sixsmith | Katharina Müller-Elmau | ||
| Charlie Murphy | Kathleen | Gabrielle Pietermann | ||
| Sara Stewart | Marcia Weller | Katrin Fröhlich Katrin Fröhlich | ||
| Marie Jones | Mutter des Barkeepers | Lisa Kreuzer | ||
| Amy McAllister | Schwester Anunciata | Marieke Oeffinger Marieke Oeffinger | ||
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