| Schauspieler | Rolle | Synchronsprecher | ||
| Michael Sheen Michael Sheen | Dr. William 'Bill' Masters | Wolfgang Wagner | ||
| Lizzy Caplan | Virginia Johnson | Sanam Afrashteh Sanam Afrashteh | ||
| Allison Janney Allison Janney | Margaret Scully | Liane Rudolph Liane Rudolph | ||
| Judy Greer Judy Greer | Alice Logan | Tanja Geke Tanja Geke | ||
| Caitlin FitzGerald | Libby Masters | Berenice Weichert Berenice Weichert | ||
| Teddy Sears | Dr. Austin Langham | Jaron Löwenberg Jaron Löwenberg | ||
| Beau Bridges | Barton Scully | Kaspar Eichel Kaspar Eichel | ||
| Annaleigh Ashford | Betty DiMello | Damineh Hojat | ||
| Isabelle Fuhrman | Tessa Johnson (1. Stimme) | Friedel Morgenstern | ||
| Isabelle Fuhrman | Tessa Johnson (2. Stimme) | Kristina Tietz | ||
| Heléne Yorke | Jane Martin | Josephine Schmidt Josephine Schmidt | ||
| Jaeden Lieberher | Johnny Masters | Gerome Quantmeyer | ||
| Kevin Christy | Lester Linden | Christoph Banken | ||
| Pepper Binkley | Adelaide | Dana Friedrich Dana Friedrich | ||
| Pepper Binkley | Adelaide | Nadine Pasta | ||
| Johnny Sneed | Al | Boris Tessmann Boris Tessmann | ||
| Christopher Wiehl | Al Neely | Fabian Oscar Wien Fabian Oscar Wien | ||
| Yvans Jourdain | Alfred | Andreas Müller Andreas Müller | ||
| Chelsea Maidhof | Allison | Aliana Schmitz | ||
| Mark Rosing | Anästhesist | Andreas Conrad Andreas Conrad | ||
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