| Schauspieler | Rolle | Synchronsprecher | ||
| Jeff Daniels Jeff Daniels | Harry Dunne | Wolfgang Condrus Wolfgang Condrus | ||
| Jim Carrey Jim Carrey | Lloyd Christmas | Stefan Fredrich Stefan Fredrich | ||
| Rob Riggle Rob Riggle | Travis / Captain Lippincott | Johannes Berenz Johannes Berenz | ||
| Laurie Holden Laurie Holden | Adele | Christin Marquitan Christin Marquitan | ||
| Rachel Melvin | Penny | Julia Stoepel Julia Stoepel | ||
| Steve Tom | Dr. Pinchelow | Axel Lutter Axel Lutter | ||
| Kathleen Turner Kathleen Turner | Fraida Felcher | Martina Treger Martina Treger | ||
| Brady Bluhm | Billy | Julius Jellinek Julius Jellinek | ||
| Tembi Locke | Dr. Walcott | Silvia Mißbach | ||
| Don Lake | Dr. Meldmann | Reinhard Kuhnert Reinhard Kuhnert | ||
| Brett Wyman | Erfinder #2 | Jeffrey Wipprecht Jeffrey Wipprecht | ||
| Eddie Shin | Gordy | Tobias Nath Tobias Nath | ||
| Bill Murray Bill Murray | Ice Pick | Dirk Müller | ||
| Atkins Estimond | Gus | Julien Haggége Julien Haggége | ||
| Jeff Sumner | Kongress-Mitarbeiter | Christian Gaul Christian Gaul | ||
| Grant James | Mr. Stainer | Reinhard Scheunemann Reinhard Scheunemann | ||
| Jo Helton | Mrs. Snergle | Evelyn Gressmann | ||
| Patricia French | Ms. Sourpuss | Isabella Grothe | ||
| Paul Blackthorne | Notfallarzt | Dennis Schmidt-Foß Dennis Schmidt-Foß | ||
| Lindsay Ayliffe | Professor Garabedian | Oliver Siebeck Oliver Siebeck | ||
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