| Schauspieler | Rolle | Synchronsprecher | ||
| RZA | Biker | Matti Klemm Matti Klemm | ||
| Taraji P. Henson | Disco Donna | Dela Dabulamanzi | ||
| Russell Brand | Dr. Nefario | Patrick Winczewski Patrick Winczewski | ||
| Danny Trejo Danny Trejo | Eisenfaust | Tilo Schmitz Tilo Schmitz | ||
| Steve Carell Steve Carell | Gru | Oliver Rohrbeck Oliver Rohrbeck | ||
| Julie Andrews | Grus Mutter | Kerstin Sanders-Dornseif | ||
| John DiMaggio John DiMaggio | Handlanger #3 | Sven Brieger Sven Brieger | ||
| Jean-Claude van Damme Jean-Claude van Damme | Jean-Klaue | Bastian Baker | ||
| Michelle Yeoh | Meisterin Chow | Meylan Chao | ||
| Will Arnett Will Arnett | Mr. Perkins | Axel Lutter Axel Lutter | ||
| Lucy Lawless Lucy Lawless | Nonnchaku | Larissa Marolt | ||
| Steve Coogan Steve Coogan | Silas Ramspopo | Bernd Egger Bernd Egger | ||
| Dolph Lundgren Dolph Lundgren | Skandinator | Oliver Stritzel Oliver Stritzel | ||
| Alan Arkin Alan Arkin | wilder Knöchelknacker | Thomas Gottschalk | ||
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