| Schauspieler | Rolle | Synchronsprecher | ||
| Rosamund Pike Rosamund Pike | Marie Curie | Alexandra Wilcke Alexandra Wilcke | ||
| Sian Brooke | Bronia Sklodowska | Giuliana Jakobeit | ||
| Demetri Goritsas | Dr. Jenkins | Peter Flechtner Peter Flechtner | ||
| Cara Bossom | Ève Curie (11) | Helen Malin Blaschke | ||
| Isabella Miles | Ève Curie (4) | Bonny von Lenski | ||
| Péter Fancsikai | Henrik | Michael Ernst | ||
| Ariella Glaser | Irène Curie (11) | Melanie Euler | ||
| Anya Taylor-Joy Anya Taylor-Joy | Irène Curie (18) | Lina Rabea Mohr Lina Rabea Mohr | ||
| Indica Watson | Irène Curie (6) | Annika Theusner | ||
| Katherine Parkinson | Jeanne Langevin | Eva Thärichen | ||
| Richard Pepple | Lester Jackson | Samuel Zekarias | ||
| Aneurin Barnard | Paul Langevin | Karim El Kammouchi Karim El Kammouchi | ||
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