| Schauspieler | Rolle | Synchronsprecher | ||
| Alan Rickman Alan Rickman | Dr. Alfred Blalock | Lothar Blumhagen Lothar Blumhagen | ||
| Mos Def | Vivien Thomas | Simon Jäger Simon Jäger | ||
| Gabrielle Union | Clara Thomas | Ghadah Al-Akel | ||
| Mary Stuart Masterson | Dr. Helen Taussig | Melanie Pukaß Melanie Pukaß | ||
| Bolton Marsh | Dr. William P. Longmire Jr. | Frank Schröder | ||
| Clayton LeBouef | Harold Thomas | Charles Rettinghaus Charles Rettinghaus | ||
| Kyra Sedgwick Kyra Sedgwick | Mary Blalok | Martina Treger Martina Treger | ||
| John Leslie Wolfe | Walter | Kaspar Eichel Kaspar Eichel | ||
| Charles S. Dutton Charles S. Dutton | William Thomas | Jürgen Kluckert Jürgen Kluckert | ||
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