| Schauspieler | Rolle | Synchronsprecher | ||
| James D'Arcy | Sherlock Holmes | Markus Pfeiffer Markus Pfeiffer | ||
| Roger Morlidge | Dr. Watson | Gerrit Schmidt-Foß Gerrit Schmidt-Foß | ||
| Vincent D'Onofrio | Prof. Moriarty | Boris Tessmann Boris Tessmann | ||
| Gabrielle Anwar | Rebecca Doyle | Christin Marquitan Christin Marquitan | ||
| Richard E. Grant | Mycroft Holmes | Stefan Staudinger Stefan Staudinger | ||
| Struan Rodger | Ben Harrington | Bodo Wolf Bodo Wolf | ||
| Peter-Hugo Daly | Henry Coot | Dirk Müller | ||
| Nicholas Gecks | Insp. Lestrade | Eberhard Haar | ||
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